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The type of model and canonical link function used varied depending on the response variable analysed. The amounts of mRNA were normalized to that of GAPDH.

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Geographical regions were included to represent booming or declining regional economies (6 counties in Finland, reference region Uusimaa).

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Note: All outcome variables are standardized to mean zero and variance one. Hydrogen atoms not involved in these interactions were omitted in regard to clarity.

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